Public Service Information About Vitamin D

An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency.[1-3] This is mostly attributable to people getting less sun exposure because of climate, lifestyle, and concerns about skin cancer. The 1997 Dietary Reference Intake (DRI) values for vitamin D, initially established to prevent rickets and osteomalacia, are considered too low by many experts.[4] DRI values are 200 IU for infants, children, adults up to age 50 years, and pregnant and lactating women; 400 IU for adults aged 50 to 70 years; and 600 IU for adults older than 70 years. Current studies suggest that we may need more vitamin D than presently recommended to prevent chronic disease. Emerging research supports the possible role of vitamin D in protecting against cancer, heart disease, fractures and falls, autoimmune diseases, influenza, type 2 diabetes, and depression. Many health care providers have increased their recommendations for vitamin D supplementation to at least 1,000 IU.[5] As a result, more patients are asking their pharmacists about supplementing with vitamin D.

The statements above are meant to be Public Service as Vitamin D deficiency is a well documented phenomena. Research on it is ongoing as you will see in the 33 References below. Because our product contains 1000 IU of Vitamin D does not mean you will obtain any of the benefits so mentioned as to Vitamin D by various researchers and authors, and no claims of any kind are being made.

References:

1.Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-281.

2.Gordon CM, DePeter KC, Feldman HA, et al. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med. 2004;158:531-537.

3.Lips P, Hosking D, Lippuner K, et al. The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med. 2006;260:245-254.

4.Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Chapter 7. Vitamin D. www.nal.usda.gov Accessed August 2, 2010.

5.Harvard School of Public Health Nutrition Source. Vitamin D and health. www.hsph.harvard.edu. Accessed August 30, 2010.

6.NIH Office of Dietary Supplements. Dietary supplement fact sheet: vitamin D. www.ods.od.nih.gov. Accessed August, 4, 2010.

7.Nair S. Symptoms of low vitamin D levels. www.buzzle.com. Accessed September 2, 2010.

8.MedlinePlus. 25-hydroxy vitamin D test. www.nlm.nih.gov. Accessed August 4, 2010.

9.Moyad MA. Vitamin D: a rapid review: side effects and toxicity. www.medscape.com. Accessed September 2, 2010.

10.Lappe JM, Travers-Gustafson D, Davies KM, et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007;85:1586-1591.

11.Ahn J, Peters U, Albanes D, et al. Serum vitamin D concentration and prostate cancer risk: a nested case-control study. J Natl Cancer Inst. 2008;100:796-804.

12.Chlebowski RT, Johnson KC, Kooperberg C, et al. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst. 2008;100:1581-1591.

13.Stolzenberg-Solomon RZ, Vieth R, Azad A, et al. A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res. 2006;66:10213-10219.

14.Stolzenberg-Solomon RZ, Hayes RB, Horst RL, et al. Serum vitamin D and risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian Screening Trial. Cancer Res. 2009;69:1439-1447.

15.Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503-511.

16.Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168:1174-1180.

17.Forman JP, Giovannucci E, Holmes MD, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49:1063-1069.

18.Liebman B. From sun & sea: new study puts vitamin D & omega-3s to the test. Nutrition Action Healthletter. November 2009:3-7.

19.Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. 2009;169:551-561.

20.Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134:1129-1140.

21.Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296:2832-2838.

22.Hyppönen E, Läärä E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500-1503.

23.Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91:1255-1260.

24.Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007;30:980-986.

25.Jorde R, Sneve M, Figenschau Y, et al. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. J Intern Med. 2008;264:599-609.

26.Cannell JJ, Vieth R, Willett W, et al. Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic. Ann Otol Rhinol Laryngol. 2008;117:864-870.

27.HealthTree.com. Vitamin D and calcium supplements. www.healthtree.com. Accessed September 2, 2010.

28.Moyad MA. Vitamin D: a rapid review: dosage of vitamin D needed to achieve 35 to 40 ng/ml (90-100 nmol/L). www.medscape.com. Accessed August 4, 2010.

29.The Nutrition Source. Ask the expert: vitamin D and chronic disease. www.hsph.harvard.edu. Accessed August 4, 2010.

30.Institute of Medicine. Dietary Reference Intakes for vitamin D and calcium. www.iom.edu. Accessed August 2, 2010.

31.The Vitamin D and Omega-3 Trial (VITAL). www.vitalstudy.org. Accessed August 2, 2010.

32.Lau AH, How PP. The role of the pharmacist in the identification and management of secondary hyperparathyroidism. US Pharm. 2007;32(7):62-72.

33.Cannell JJ. Vitamin D pharmacology. www.vitamindcouncil.org. Accessed August 30, 2010.